%0 Journal Article %A Olga Mardanova %A Vladimir T. Ivashkin %T Influence of systemic inflammation and hypoxaemia on bone metabolism in patients with chronic obstructive pulmonary disease (COPD) %D 2013 %J European Respiratory Journal %P P1538 %V 42 %N Suppl 57 %X The aim of our study was to access the influence of systemic inflammation and hypoxaemia on bone metabolism in patients with chronic obstructive pulmonary disease (COPD).Materials and methods. The prospective cohort study was conducted. 33 male and 10 female patients with COPD over 55 years old were included.View this table:General characteristics of patients groupIn patients was assessed bone mineral density, SpO2, the blood level of leukocytes, fibrinogen, C-reactive protein, TNF-alfa, IL-6, osteocalcin, C-telopeptids.Results: In patients with COPD the negative correlation between the T-score of the femoral neck and the fibrinogen blood level (r=-0,43, p<0,05) was determined. In patients with increased IL-6 blood level the amount of osteocalcin was significantly lower than in patients without increasing (p<0,05). We have also found, that there was a negative correlation between the blood amount of leukocytes and osteocalcin level (r=-0,403, p<0,05). In group of patients with respiratory failure T-score of the femoral neck was significantly lower than in patients without respiratory failure (-1,56±0,25 SD and -0,73±0,2 SD, p<0,05).Conclusions: either increased level of systemic inflammation markers or hypoxaemia causes decreasing of bone mineral density and depression of osteoblasts activity in patients with COPD. %U https://erj.ersjournals.com/content/erj/42/Suppl_57/P1538.full.pdf