PT  - JOURNAL ARTICLE
AU  - Eid Al Mutairy
AU  - Naeem Chaudhri
AU  - Mahmoud Al Jurf
AU  - Abdullah Al Dalaan
AU  - Saud Erwi
AU  - Sarfraz Saleemi
AU  - Mohammed Khalid
TI  - Effect of allogenic bone marrow transplant on cardiac function and pulmonary vascular pressure
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P4978
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P4978.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P4978.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Aims and Objectives:Pulmonary infections, fibrosis and bronchiolitis obliterans (BOS) in post bone marrow transplant (BMT) are frequent, cardiac and pulmonary vascular involvement in post BMT has not been studied well.Materials and Methods:Prospective evaluation of ten patients with diagnosis of post BMT/Graft-Versus-Host Disease (GVHD) syndrome and BOS. Patient’s echocardiogram were evaluated for cardiac function and pulmonary artery pressure, pulmonary function test (PFT) were evaluated for severity of lung disease, standard ATS Criteria.Results:All patients had normal cardiac function and normal pulmonary artery pressure prior to BMT. 7/10 (70%) patients developed Lt. ventricular dysfunction. 5/10 (50%) patients developed pulmonary hypertension (PHT).View this table:Echo s/p BM TXCardiac and pulmonary vascular involvement was independent of severity of lung disease on PFT.Discussion:Our study shows significant cardiac dysfunction with PHT in post BMT patients. It could be related to pre transplant induction therapy or part of GVHD, this aspect should be considered in patients evaluation and management.Conclusion:Left ventricular dysfunction and PHT is a significant problem in post BMT patients. Its causes and potential management needs further evaluation.