RT Journal Article SR Electronic T1 Does the HLA-DRB1-genotype influence the course of disease in Danish sarcoidosis patients? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 3067 VO 42 IS Suppl 57 A1 Nils Milman A1 Thomas van Overeem Hansen A1 Michael Skov Jensen A1 Claus Bo Svendsen A1 Klaus Richter Larsen YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/3067.abstract AB Background: The MHC class II region plays an important role in sarcoidosis, due to modulation of the immune response. HLA-DRB1*15 is associated with non-resolving disease in Swedish sarcoidosis patients (Grunewald et al. Respiratory Research 2010, 11:25). We evaluated the influence of the DRB1-genotype in Danish sarcoidosis patients.Subjects and methods: DRB1-genotyping was performed by PCR in 85 ethnic Danish sarcoidosis patients (52 men). Age at diagnosis was median 34 years (range 1-72). The follow-up period was median 37 months (range 0-516).Results: The prevalence of DRB1*01 was lower (p=0.0040) and the prevalence of DRB1*15 higher (p=0.00006) in sarcoidosis patients compared to controls. At follow-up, DRB1*07 was associated with a significantly lower frequency of non-resolving disease >2 years, whereas DRB1*15 was associated with a significantly higher frequency of non-resolving disease.View this table:Table 1. Course of sarcoid disease according to DRB1-genotypesHowever, there were no significant differences between the DRB1-genotype groups concerning lung function tests (FEV1%, FVC%, DLCO% predicted) and chest X-ray stages according to Scadding.Conclusions: We have no biochemical markers of sarcoidosis. When the diagnosis has been confirmed, the DRB1-genotype may be used to predict the course of disease. In contrast to Swedish studies we found that DRB1*07 was associated with resolving disease, while our results confirmed the established association between DRB1*15 and non-resolving disease.