RT Journal Article
SR Electronic
T1 Gas exchange in health, lung disease and elite athletes: Diffusion capacity for carbon monoxide in children at rest and with exercise
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1486
VO 42
IS Suppl 57
A1 Nicholas Fitzgerald
A1 Brendan Kennedy
A1 Dominic Fitzgerald
A1 Hiran Selvadurai
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/1486.abstract
AB Rationale: Decreased DLCO after exercise is reported in adults. There is limited information for post exercise DLCO available in children.Objectives: [1] Test reproducibility of DLCO in children, [2] compare DLCO between elite athletic swimmers [AS], stable cystic fibrosis patients [CF] and controls [Con] at rest & [3] after a maximal treadmill exercise test.Methods: 55 subjects (10 – 18 years) performed spirometry & DLCO at baseline, a maximal treadmill exercise test & repeated DLCOs for 2 hours post exercise.Results: [1] The mean [SD] co-efficient of variation between baseline DLCO tests was 2.49% [1.86%]. There was a uniformity of variance as the mean baseline DLCO rises[r = -0.077; p=0.59]. [2] AS had significantly larger FEV1% & FVC% compared to both CF & Con groups [p<0.001] & the Con group was significantly larger than the CF group [p<0.001]. AS had a higher baseline DLCO compared to CF & Con groups [p<0.01]. [3] There were no differences in mean decrease in DLCO from baseline between groups in girls, however male AS[-17.7%] were significantly different to CF[-6.92%] & Con[-9.23%][ P<0.05].Conclusions: DLCO is highly repeatable in children. AS have larger lung volumes, expiratory flows & an increased DLCO at rest compared to CF children & controls. Decline in post exercise DLCO & the pattern of change in DLCO after exercise is similar in children to adults.