TY - JOUR T1 - Evaluation of urinary cotinine levels in children with chronic cough JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P851 AU - Yesim Ozdemir AU - Ilknur Bostanci AU - Çigdem Özdilekcan AU - Serap Ozmen AU - Handan Duman Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P851.abstract N2 - Aim: Our study is planned to reveal the objective relation between urine cotinine level and passive smoking and /or third hand tobacco smoke exposure in children suffering from chronic cough.Material and Methods: Between ages 5-18, 58 patients with chronic cough and 54 healthy individuals; children are included in the study. Cases are divided into two groups according to their passive smoke exposure (exposed or unexposed group).Results: There was a statistically significant difference between urine cotinine levels of cases those who exposed and unexposed (based on the declaration of parents) to tobacco smoke (p<0, 05). The highest mean value of cotinine (41, 3±73, 7) is detected in the cases of chronic cough group who exposed to smoke. The best cut-off value to define the groups exposed and unexposed has been found as 12.15 ng/ml with ROC analyze. Smoking ratio during pregnancy and daily number of cigarette has been found more in the group with chronic cough (p<0, 05). FEV1/FVC ratio has found to be lower in patients with chronic cough who are passive smokers when compared with the cases in the other groups (p<0,05).Conclusion: There are few studies indicating the relation between chronic cough and environmental tobacco smoke exposure and there are no objective studies in the previous literature showing the relation between chronic cough in the childhood and passive smoking. This is the first study objectively evaluating chronic cough effect of passive smoking with urine cotinine level. Since there is a meaningful decrease in FEV1/FVC ratio, close follow up is needed especially in children diagnosed as chronic cough who are exposed to tobacco smoke. ER -