TY - JOUR T1 - Elevated survivin is associated with a reduced survival in patients with malignant pleural effusion JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 1518 AU - Didem Görgün AU - Pinar Yildiz AU - Funda Secik AU - Kenan Midilli AU - Vakur Akkaya Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/1518.abstract N2 - We aimed to show the prognostic value of survivin levels in malignant pleural effusion (MPE). METHODS: Fifty-one MPE patients were included in our study prospectively. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 51 effusion. The correlation between survivin level and survival in MPE were analyzed. RESULTS: Survivin level was 41.75 ± 76.20 in patients with MPE. There was no correlation between survivin level and age, sex, location, fluid pH, glucose, protein, albumine and ADA level while there was significant moderate correlation with fluid LDH (r=0.49; p<0.001). Elevated levels of survivin was related to reduced overall survival in Kaplan-Meier analysis. Survivin levels can distinguish patients who had poor prognosis (median survival 75 days, n=24) and those who had good prognosis (median survival 219 days, n=27, p=0.03) in MPE. Cox regression analysis was carried out for significant factors influencing survival. Survivin level, fluid LDH level and tumor type were included as independent factors. Only survivin level was retained as significant in backward elimination likelihood ratio test.In conclusion, elevated survivin levels is associated with poor survival in MPE. Our results suggest that survivin may be used as a prognostic marker in MPE. ER -