TY - JOUR T1 - Obstructive sleep apnea syndrome (OSA) and hypercoagulability - What is the impact of sole OSA in the absence of comorbities? JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4005 AU - Nadine Baschung AU - Corinne Roth AU - Anne-Kathrin Brill AU - Thomas Geiser AU - Matthias Gugger AU - Sebastian Ott Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4005.abstract N2 - Aim:OSA is a known risk factor for cardiovascular morbidity and mortality. Among others, OSA-induced hypercoagulability has been identified as a potentially unterlying mechanism. So far, it remains unclear whether changes in the coagulation system are caused by OSA alone or by OSA-associated comorbidities. The aim of this study was to investigate the influence of sole OSA on various hemostatic parameters and markers of platelet activation (INR, aPTT, prothrombin time (PT), plasminogen, plasminogen activator inhibitor-1, fibrinogen, sCD40 ligand, platelet derived microparticles).Methods: We studied 10 otherwise healthy male patients with newly diagnosed OSA and 10 male non-OSAS controls with comparable demographics. OSA was proven or excluded by full-night polysomnography (PSG). Following PSG, fasting blood was drawn between 6:00 a.m. and 7:00 a.m. prior to physical activity.Results: Most parameters of hemostasis and platelet activation did not differ between sole OSA patients and healthy controls. Only PT (12.0±0.6 s vs. 12.8±0.5 s, p<0.05) and fibrinogen (3.2±0.6g/l vs. 2.5±0.7g/l, p<0.05) showed significantly different values, but still within normal range, possibly indicating a procoagulatory state in OSAS patients without comorbidity.Conclusions: Our data suggest that sole OSA contributes only a small proportion to the previously described procoagulatory state, thus, limiting the hitherto assumed direct impact of OSA on the coagulation system. OSA associated comorbidities and simultaneously existing cardiovascular risk factors are probably the major contributors to hypercoagulability in OSA patients, possibly aggravated by a concomittant OSA. ER -