PT  - JOURNAL ARTICLE
AU  - Haruka Aoki
AU  - Takeshi Hisada
AU  - Masakiyo Yatomi
AU  - Hiroaki Tsurumaki
AU  - Reiko Yoshino
AU  - Kunio Dobashi
AU  - Tamotsu Ishizuka
AU  - Masatomo Mori
TI  - Relevance of hemoglobin A1c and acute exacerbations of chronic obstructive pulmonary disease
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P773
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P773.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P773.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background and objectiveHyperglycaemia during hospital admission is associated with poor outcomes in patients admitted with acute myocardial infarction, stroke and pneumonia. Systemic inflammation may represent a possible cause of glycometabolic disorder. We proposed that is associated with an increased risk of acute exacerbation of COPD (AECOPD).MethodsPatients with COPD were prospectively enrolled and followed between 2009 and 2013. Medical records, HbA1c, fasting glucose and metabolic markers were assessed in 56 COPD patients.ResultsA total of 56 patients (mean age of 75.7years) were recruited, 18 with AECOPD and 38 without. Clinical data were collected from the patients. HbA1c levels of AECOPD patients were significantly higher on entry point compared with other patients (5.78±0.26; 4.98±0.18, respectively p=0.0361). A negative association between total cholesterol and LDL cholesterol were observed. Moreover, HbA1c tended to increase at AECOPD (+0.3±0.07).ConclusionPrevious study revealed that comorbid diabetes prolongs length of stay and increases risk of death in patients with AECOPD. However, less evidence exists for relationship of HbA1c with AECOPD. For the first time our study demonstrates that HbA1c is a prognostic factor associated with AECOPD.