PT  - JOURNAL ARTICLE
AU  - Qingling Zhnag
AU  - E. Guo
AU  - Naijian Li
AU  - Mengzhang He
AU  - Jing Li
AU  - Jingping Zheng
TI  - Relationships between exhaled nitric oxide and lung function profiles in severe asthma
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P770
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P770.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P770.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - OBJECTIVE:To examine whether fractional exhaled nitric oxide (FeNO) levels are associated with lung function in severe asthmatics.METHOD:A total of 24 non-smoking stable severe asthmatics underwent an assessment that included FeNO measurements, spirometry [including forced expiratory volume at the first second (FEV1), forced volume capacity (FVC), forced expiratory flow at 25–75% of volume capacity (FEF25–75), peak expiratory flow(PEF)], bronchial reversibility and patient characteristics, i.e. asthma control questionnaire 5 (ACQ5), gender, obesity (defined as BMI ≥ 25 kg/m2), nasal disease, duration of asthma, exacerbation times in the past year. All patients had been attending the clinic for at least 6 months and had undergone a Severe Asthma Protocol for confirmation of the diagnosis of severe asthma.RESULTS:Mean FeNo of the subjects was 40±31.33ppb.FeNO levels varied according to the gender. A positive correlation was found between FeNO and FVC,PEF and ΔFEV1 after bronchodilator. There appears to be no correlation between FeNO and nasal diseases, ACQ5, duration of asthma and excarbation times in the past year.CONCLUSION:FeNO levels varied according to the gender. A positive correlation was found between FeNO and FVC,PEF and ΔFEV1 after broncodilator. The value of FeNO measurement in severe asthma need further additional research.