TY - JOUR T1 - Burden of comorbidities and NT-proBNP concentrations in stable COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3741 AU - Laura Caram AU - Renata Ferrari AU - André Bertani AU - Liana Coelho AU - Suzana Minamoto AU - Irma Godoy Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3741.abstract N2 - The relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and COPD severity is not yet well established in the literature. Studies have evaluated the concentrations of NT-proBNP in COPD patients; however, few studies evaluated this association according to GOLD. The aim of this study was to compare and evaluate the association between NT-proBNP, COPD severity, smoking history and concentrations of inflammatory mediators in 50 COPD patients classified according to GOLD (25 COPD mild/moderate and 25 COPD severe/very severe). All individuals underwent to medical history and physical examination, clinical and laboratory assessments, pre-and post-bronchodilator spirometry and comorbidities (Charlson index). Interleukin (IL6), NT-proBNP concentrations and echocardiography were performed. Concentrations of NT-proBNP did not differ statistically between groups [COPD mild/moderate:135.60(73.65-268.75),p=0.58] and COPD severe/very severe:100.80(62.75-149.00),p=0.58]. Smoking history, IL6 and left ventricular diastolic diameter (LVD) also did not differ between groups. FEV1, smoking history, LVD, IL6 and Charlson index were included as independent variables in the multiple linear regression to identify the factors associated with NT-proBNP concentrations. Only the Charlson index showed positive association with concentrations of NT-proBNP [r2=0.40, 80.27(15.07-145.48),p=0.01]. In conclusion, NT-proBNP concentrations did not differ according disease severity. However, the presence of comorbidities is associated with increased NT-proBNP concentrations, suggesting values of NT-proBNP are related to the bunder of comorbidities in COPD patients. ER -