RT Journal Article
SR Electronic
T1 Association between markers of aggressiveness of malignant cutaneous melanoma and sleep disordered-breathing
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3045
VO 42
IS Suppl 57
A1 Francisco Campos-Rodriguez
A1 Miguel A. Martinez-Garcia
A1 Antonio Martorell-Calatayud
A1 Amalia Perez-Gil
A1 Eduardo Nagore
A1 Irene Valero-Sanchez
A1 Maria J. Selma-Ferrer
A1 Eusebi Chiner-Vives
A1 Pedro Landete
A1 Josep M. Montserrat
A1 Cristina Carreras
A1 Ramon Farre
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/3045.abstract
AB Background. Recent studies in humans have shown an association between sleep-disordered breathing (SDB), including overnight hypoxia, and the incidence and mortality of cancer, but no study has focused on a specific type of cancer. The objective of this study was to analyze the relationship between some markers of cutaneous malignant melanoma (CMM) aggressiveness and the severity of SDB.Methods. We performed a prospective, multicenter observational study in 56 consecutive patients diagnosed with CMM. Measurements of CMM aggressiveness included: number of mitosis/mm2, Breslow Index, presence of ulceration and growth rate of melanoma (GRM). Every participant underwent a diagnostic respiratory polygraphy. Multivariate analyses were used to investigate the independent relationship between SDB severity measured by the apnoea-hypopnoea index (AHI) and oxygen desaturation indexes (ODI3% and ODI4%) and markers of CMM aggressiveness.Results. The prevalence of SDB (AHI≥5) in the cohort was 60.7% and severe SDB (AHI≥30) was present in 14.3% of the patients. In fully adjusted multivariate analyses, AHI (OR 1.17; 95%CI 1.03-1.34), ODI3% (OR 1.14; 95%CI 1.03-1.26) and ODI4% (OR 1.3; 95%CI 1.04-1.45) were independently associated with an increased GRM. Furthermore, AHI, ODI4% and ODI3% correlated with other aggressiveness factors of CMM, such as the Breslow Index, presence of ulceration and mitotic index.Conclusion. SDB severity independently predicts aggressiveness of cutaneous malignant melanoma.