TY - JOUR T1 - U-BIOPRED asthma cohort: Inflammatory markers and corticosteroid use JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 3029 AU - D. Gibeon AU - A.H. Wagener AU - X. Yang AU - A.R. Sousa AU - J. Corfield AU - D.E. Shaw AU - S. Fowler AU - L.J. Fleming AU - J. Riley AU - E. Jeyasingham AU - A. Rowe AU - K. Fichtner AU - G. Roberts AU - P. Bakke AU - F. Singer AU - T. Geiser AU - U. Frey AU - I. Horvarth AU - R. Polosa AU - K. Bønnelykke AU - N. Krug AU - R. Middelveld AU - S.-E. Dahlen AU - B. Dahlen AU - G. Hedlin AU - S. Hashimoto AU - B. Nordlund AU - J. Musial AU - A. Woodcock AU - C.S. Murray AU - L. Pahus AU - P. Chanez AU - D. Myles AU - C. Compton AU - T.W. Higenbottam AU - P. Montuschi AU - J. Vestbo AU - L. Larsson AU - T. Sandstrom AU - H. Bisgaard AU - S.S. Wagers AU - P.H. Howarth AU - E.H. Bel AU - R. Djukanovic AU - P.J. Sterk AU - K.F. Chung Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/3029.abstract N2 - Rationale: U-BIOPRED, a European public-private collaboration, aims to sub-phenotype severe asthma using a systems medicine approach to describe its handprint.Methods: An interim analysis of the characteristics and inflammatory markers of severe asthma defined according to Thorax 2011; 66: 910 is presented.View this table:NA: not availableResults: The adult severe asthma cohort had chronic airflow obstruction, with higher sputum eosinophils (SpE) compared to moderate asthma. The school-age severe asthma cohort had no evidence of obstruction but higher FeNO levels than moderate asthma. Pre-bronchodilator FEV1 (% pred) in adults inversely correlated with SpE and neutrophils, while SpE positively correlated with FeNO. In children, preBD FEV1 inversely correlated with FeNO. Analysis of the adult cohort according to use of maintenance prednisolone showed that this subphenotype was associated with lower IgE and blood eosinophil level, but similar SpE and FeNO.Conclusions: Severe asthma patients characterised by high SpE and FeNO despite high corticosteroid therapy, represents a steroid-insensitive subgroup. Analysis of associated lipidomic, transcriptomic and proteomic data will provide a better handprint. ER -