PT  - JOURNAL ARTICLE
AU  - Anna Delieva
AU  - Liuba Dolinina
AU  - Vasilij Trofimov
TI  - The level of anti-inflammatory cytokine IL-10 in patients with chronic obstructive pulmonary disease of varying severity
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P600
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P600.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P600.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Imbalance in the system cytokines in patients with COPD is an important pathogenic mechanism of development and progression of chronic persistent inflammation.Purpose: To study the level of anti-inflammatory cytokine IL-10 in bronchial secretions and serum of patients with COPD of varying severity, to analyze the effect of anti-inflammatory therapy.We examined 112 patients with COPD of varying severity. The greatest value of IL-10 was detected in patients with mild COPD (26,72 ± 3,48 pg / ml in sputum, 13,43 ± 0,17 pc / ml in bronchial washings, 19,03 ± 1,39 pg / ml in serum compared with more severe. With increasing severity of COPD, the level of IL-10 decreased in all body fluids: for very severe COPD level of IL-10 in sputum 16,42 ± 6,06 pg / ml washes bronchial 0,38 ± 0,12 pg / ml (p <0.05), serum 9,52 ± 0,87 pg / ml.There was a negative correlation between the level of IL-8 and IL-10 sputum (r = -0, 40, p = 0.008), with increased activity of the inflammatory cytokine IL-8 level reduced and IL-10.The level of IL-10 in sputum, bronchial lavage and serum of patients who had not received inhaled corticosteroids did not differ significantly from the level of IL-10 patients received inhaled anti-inflammatory therapy.Conclusion: Receiving inhaled glucocorticosteroids does not affect the anti-inflammatory cytokine IL-10 directly, but it can have an indirect effect, reducing the activity of pro-inflammatory cytokines. High activity of pro-inflammatory cytokines in severe COPD may inhibit the synthesis of IL-10.