RT Journal Article
SR Electronic
T1 Intensity of daily activity may affect exercise capacity and peripheral muscle function in adults with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3602
VO 42
IS Suppl 57
A1 Daniela Savi
A1 Paolo Onorati
A1 Marcello Di Paolo
A1 Francesca Megiorni
A1 Riccardo Valerio De Biase
A1 Emanuela Leggieri
A1 Francesca Alatri
A1 Tamara Perelli
A1 Fabio Midulla
A1 Serena Quattrucci
A1 Paolo Palange
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3602.abstract
AB Introduction. Data obtained in young cystic fibrosis (CF) patients suggest that improving daily physical activity (PA) may have a positive impact on exercise tolerance, on nutritional status and on the rate of decline of FEV1; moreover, it seems to have beneficial effects on sputum clearance, respiratory muscle strength and quality of life. To date, less is known in adult patients about the role that PA intensity play to the patients’ functional status. Methods. 20 CF patients (mean age 33±8SD yrs; FEV1 2.6±0.6 l; FEV1 68±16 % predicted) were studied at rest and during symptom-limited incremental exercise test (CPET). We measured hand-grip strength using a hydraulic hand dynamometer and we assessed daily PA using SenseWear (SW) accelerometer that subjects wore for 4 consecutive days. Results. A close relathionship was observed between vigorous SW activities and both VO2 peak and Watt max (r=0.545, p=0.01; r=0.547, p=0.01); a good relationship was observed between SW activities of moderate intensity vs VO2 peak (r=0.503; p=0.02) and vs V’E peak (r=0.436, p=0.05). Hand-grip strength was significantly related with both SW daily physical activity of moderate (r=0.431; p=0.05) and vigorous (r=0.508; p=0.02) intensity. SW mild physical activity was not correlated to muscle and exercise variables. Conclusions: In adult CF patients with mild to moderate lung obstruction PA levels of moderate intensity and above are related to exercise tolerance. Specifically, only daily life activity above moderate intensity seems to maintain physical fitness and peripheral muscle function. Encouraging exercise with moderate intensity to be a part of therapy should be recommended.