%0 Journal Article %A Balakrishnan Menon %A Gaki Nema %A Charanjeet Kaur %T Evaluation of vitamin D in bronchial asthma and its correlation with lung function %D 2013 %J European Respiratory Journal %P P4700 %V 42 %N Suppl 57 %X BACKGROUND :Low levels of vitamin D (VitD) has been associated with poor asthma control and reduced lung function. Also higher VitD levels are associated with decreased airway hyperresponsiveness and decreased inflammatory markers.AIMS :To evaluale VitD levels in asthmatics and to correlate it with lung functionMETHODS :One hundred forty three new patients of asthma were recruited and classified as per GINA guidelines. Spirometry was performed and VitD (25 OH Cholecalceferol) was estimated by ELISA method. VitD was also estimated in 10 healthy volunteers for control purposes.RESULTS :Of the 143 asthmatics, 34 were in mild persistent group, 74 were moderate persistent and 35 were in severe persistent group.The mean value of VitD in asthmatics was 16.43±8.4ng/ml and in controls was 28.21+4.7ng/ml. The difference in means was found to be highly significant (p<0.01). The mean FVC in asthmatics was 3.26±0.8L. The FEV1 was 2.41±0.7L.The mean VitD levels in mild persistent group was 18.68±8.3ng/ml, in moderate persistent group was 16.42±9.4ng/ml and in severe persistent group was 14.33±5.9ng/ml. The difference of means was significant (p<0.05).Significant positive correlation was found between FEV1 and FVC (p<0.01) and between VitD and serum total IgE levels (p<0.05). However no significant correlation was obtained between VitD levels and FVC and FEV1.CONCLUSION :Vitamin D levels were found to be low in both controls and patients of asthma. The difference in VitD levels between asthmatics and controls was highly significant. Also the difference in VitD levels between the different stages of asthma was significant. No significant correlation was obtained between VitD levels and lung function parameters. %U https://erj.ersjournals.com/content/erj/42/Suppl_57/P4700.full.pdf