RT Journal Article
SR Electronic
T1 Obstructive sleep apnea syndrome as factor of arrhythmic syndrome emergence and increase of cardiovascular risk in patients with COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2573
VO 42
IS Suppl 57
A1 O.S. Khmel'
A1 V.V. Rodionova
A1 L.A. Glinyana
A1 N.A. But
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2573.abstract
AB Purpose:to define the correlation between degree of cardiovascular risk, obstructive sleep apnea syndrome(OSAS), and frequency of arrhythmias in patients with chronic obstructive pulmonary diseases(COPD).Design:were examined 42 patients in the age of 57,63±2,78 years with COPD stage II(83%) and stage III(17%)(GOLD 2011). Duration of disease was 11-23 years.64% of patients were smoking, index of smoking-15,3±0,52 pack-years. Control group included 15 practically healthy persons. Basic therapy was held according to GOLD2011.Methods:Holter monitor test with spectral analysis of heart rhythm variability, rheopneumography with definition of apnoea/hypopnoea index(AHI), six-minute walk test(6MWT), calculation of cardiovascular risk according to the scale SCORE.Results:69% of patients had OSAS of mild and 24% - of moderate stage(p<0,05). Patients had from 163 to 2282 cases of cardiac rhythm disturbances within 24 hours: 54% - atrioventricular, 46%– ventricular extrasystoles. 62% of patients had ventricular late potentials. Were revealed correlations between AHI and 6MWT(r=-0,5684;p<0,05); Valt(r=0,7884;p<0,05); RMS40(r=-0,46;p<0,05), LAS40(r=0,72;p<0,05); rMSSD(r=0,6715;p<0,05), HFn.n.(r=0,81;p<0,05), cardiovascular risk(r=0,7618;p<0,05). Patients had evidently increased risk for fatal complications according to the scale SCORE(r=0,7853;p<0,05): high risk level in 12,6% and very high ten years' risk in 71% of cases.Conclusions:93% of patients with COPD had OSAS, evidently increased risk for life threatening arrhythmias and fatal complications.