TY - JOUR T1 - Phenotyping athlete's asthma JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3965 AU - Mariana Couto AU - Julie Stang AU - Luís Horta AU - Trine Stensrud AU - Milton Severo AU - Petter Mowinckel AU - Diana Silva AU - Luís Delgado AU - André Moreira AU - Kai-Håkon Carlsen Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3965.abstract N2 - Different phenotypes of asthma in athletes have been suggested by logistic regression analysis. Recent attempts to describe phenotypes are based on cluster analysis but this approach was never used for asthma in athletes. We aimed to characterize asthma phenotypes in elite athletes using a latent class analysis; and to evaluate if the type of sport practiced influences the asthma phenotype.A retrospective analysis of athlete’s files was performed in the Portuguese National Anti-Doping and the Norwegian School of Sport Sciences databases. Asthmatic athletes (according to IOC-MC criteria) giving informed consent were included for latent class analysis; the number of classes (clusters) were confirmed by the Lo-Mendell-Rubin likelihood ratio test and the Bayesian information criteria (BIC). Sports practiced were categorized by training environment into Water, Winter or Summer Sports.Files of 324 athletes were reviewed, of which 150 were asthmatic (91 Portuguese; 59 Norwegian). Latent class analysis retrieved a model with 2 clusters (BIC 1040): Class 1 (“Atopic asthma”) defined by the presence of atopy, increased FeNO, rhinitis and other allergic co-morbidities; Class 2 (“Occupational asthma”) defined by the presence of exercise-induced respiratory symptoms and bronchial hyperesponsiveness in the absence of allergic features. Considering summer sports as reference, occupational asthma associated positively with water (OR=2.87; 95%=[1.82-4.51]), and winter (OR=8.65; 95%=[2.67-28.03]) sports.These results support the 2 previously reported phenotypes of asthma in athletes, mainly differing in mechanistic pathways (e.g. atopic features). The type of sport practiced seems to influence the expression of different asthma endotypes, but larger studies are needed. ER -