TY - JOUR T1 - High-flow oxygen therapy in COPD patients: Optimised oxygen delivery JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2471 AU - Helene Vogelsinger AU - M. Halank AU - H. Wilkens AU - T. Geiser AU - S. Braun AU - S. Ott AU - A. Stucki AU - C.M. Kaehler Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2471.abstract N2 - IntroductionCOPD is a leading cause of death and is often related to chronic hypoxemia. Long-term oxygen therapy (LTOT) is a well established treatment. High-Flow oxygen treatment (HFOT), the nasal insufflation of warm, humidified air at a high flow rate, is a new and simplified method in not-invasive ventilation. Until now, no data concerning HFOT in COPD patients are available.AimOur studies were designed to assess the safety and efficacy of HFOT in COPD patients compared to conventional oxygen therapy and to examine possible changes in oxygenation.MethodsInclusion criteria: COPD °IV, indication for LTOT, 30-80 yr, clinical stable and Hb > 8.5 g/l. Oxygen (O2) supplementation was performed with a TNI® 20s oxy-system (15 L/min) or with a standard oxygen delivering system. O2 adaptation was performed in 10 min intervals until a paO2 ≥ 60mmHg was achieved. Blood gas analyses were performed from the hyperaemic earlobe.Results60 patients were enrolled: 45 male, 15 female, mean age: 66.3 yr, FEV1 (pred): 12-49 %. HFOT was well tolerated and was sensed as comfortable. A significant decrease of paCO2 could be measured (-1.45 mmHg; p = 0.018) when compared to conventional oxygen administration. Oxygen delivery trends to be lower with HFOT (-0.23 L/min). By using the high-flow system with 15 L/min the delivered mean FiO2 was 31.7 % compared to the FiO2 of 100 % delivered by conventional oxygen treatment (p = 0.0001).ConclusionIn conclusion, treatment with high-flow nasal insufflation is safe in patients with severe COPD on LTOT treatment. Lower amounts of delivered O2 seem to be necessary to oxygenate the patient. Trials for longer periods are planned to further prove efficiency of HFOT. ER -