RT Journal Article
SR Electronic
T1 Multiple primary malignancies in Japanese patients with non-small cell lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4209
VO 42
IS Suppl 57
A1 Shiro Fujita
A1 Junpei Takeshita
A1 Kosuke Tanaka
A1 Akito Hata
A1 Katsuhiro Masago
A1 Reiko Kaji
A1 Kenji Takayama
A1 Masaki Kokubo
A1 Nobuyuki Katakami
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4209.abstract
AB [Background] Information on multiple primary malignancies (PMs) is important as it has the potential to clarify etiologic factors and contribute to refining the follow-up of patients (Pts) by effectively screening the associated malignancies. Upper aerodigestive tract cancer often develops in Pts with smoking-related lung cancer, however, little is known with regard to the frequency and types of other PMs in non-small cell lung cancer (NSCLC) Pts without a history of smoking.[Patients and Methods] We retrospectively studied the records of NSCLC Pts at the Institute of Biomedical Research and Innovation between January 2007 and June 2012.[Results] A total of 938 Pts including 599 men (never-smoker/ ever-smoker: 35/564) and 339 women (never-/ ever-: 236/103) were analyzed and 209 Pts (22.3%) had multiple PMs. One hundred and seventy-eight Pts had one histologically-proven PM other than NSCLC, 27 had two other PMs and 4 had three other PMs. Of 209 Pts with multiple PMs, 151 Pts had a history of smoking and 58 were never-smokers. The most commonly found cancer was gastric, colorectal and prostate cancer (43, 33, 29 cases, respectively). In female Pts without a history of smoking, breast, thyroid and colorectal cancer (5.9, 5.1 and 3.0%, respectively) were the most prevalent malignancies. As expected, smoking-related cancer is more common in ever-smoker Pts in both genders. With regard to female NSCLC Pts, never-smoker Pts are more likely to have thyroid cancer compared to Pts with a history of smoking (5.1% and 0%, P=0.021).[Conclusion] Thyroid cancer and NSCLC co-exist in some female Pts without a history of smoking and predisposing factors other than tobacco smoke are implied.