TY - JOUR T1 - Coronary calcium and epicardial adipose tissue in patients with chronic obstructive pulmonary disease JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P233 AU - Jorge Zagaceta AU - Javier Zulueta AU - Gorka Bastarrika AU - Inmaculada Colina AU - Ana B. Alcaide AU - Arantza Campo AU - Bartolome Celli AU - Juan P. de Torres Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P233.abstract N2 - Rationale: Coronary Artery Calcium (CAC) and Epicardial Adipose Tissue (EAT) volume as determined by CT is an independent marker of cardiovascular events in the general population.Objectives: To assess CAC and EAT volume in COPD and explore its association with clinical and physiological variables of disease severity.Methods: We measured EAT and CAC using CT in 171 stable COPD patients and 70 controls matched by age, smoking history and BMI.The variables studied are shown in Table 1. Uni and multivariate analyses explored the relationship between EAT volume and the COPD related variables. Results: COPD patients had a higher EAT volume (p=0.02) but found no difference in CAC (p=0.062). In COPD patients, EAT volume was associated with (Table 2): age, pack-years, BMI, gender, FEV1%, 6MWD, MMRC and HTN.Multivariate analysis showed that only pack-years, BMI and 6MWD, predicted EAT volume. Conclusions: EAT volume is increased in COPD patients and is independently associated with smoking history, BMI and exercise capacity. EAT volume could be a non-invasive marker of COPD patients at high risk for future cardiovascular events. ER -