TY - JOUR T1 - Biopsy documented idiopathic interstitial pneumonias - Analysis of diagnostic yield, survival and mortality over 9 years JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2300 AU - Nitin Abhyankar AU - Vrushali Khadke AU - Jayshree Jain AU - Ajit Tambolkar AU - Rahul Kubde Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2300.abstract N2 - Material and Methods -78 patients underwent lung biopsy using medical thoracoscopy between 2004 till 2013.All cases had restriction on Spirometry, bilateral interstitial infiltrates,exertional dyspnoea and radiological features either nonclassical for UIP (70/78 cases) or possible UIP(8/78 cases).Results- 37/ 78 (47.43%) patients had 'UIP' IPF after biopsy and multidisciplinary discussion (also further validated on clinical and radiological follow up). 41/78 patients had 'non UIP' pattern.View this table:Biopsy documented IIPs (n = 78)Comparisons revealed younger patients (52.9 years vs 60.47 years),and longer average survival (41.34 months vs 27 months) in 'non UIP' group.( statistically not significant). Non UIP group had 6 deaths whereas UIP group had 20 deaths ( p = 0.01). 17/37 patients in the 'UIP' group never received pirfenidone. 20 patients received pirfenidone for some duration.Average survival in 'pirfenidone' group was 32.9 months vs 20.06 months in 'no pirfenidone' group.(statistically not significant) .15 patient in 'no pirfenidone' group died vs 5 deaths in 'pirfenidone' group (p=0.4801). Conclusions - 1) 47 % of lung biopsies in patients with IIP with radiological pattern not classical for UIP IPF have UIP on histopathology and clinical behaviour. 2) Non UIP diagnosis seem to be associated with younger age and better survival duration than UIP. Mortality for UIP is significantly higher than Non UIP pattern. 3) Pirfenidone may be improving survival in UIP IPF. ER -