TY - JOUR T1 - Correlation of FDG-PET/CT and EBUS-TBNA for nodal staging in lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2906 AU - Petra Hoffknecht AU - Markus Enderle AU - Gabriela May AU - Heiner Schubert AU - Stefan RĂ¼ther AU - Stefan Fischer AU - Patrick Zardo AU - Nicolas J. Dickgreber Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2906.abstract N2 - Positron emission tomography (PET/CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are standard diagnostic procedures in lymph node (ln) staging in suspected malignomas.In this retrospective single center study we aimed to investigate the efficacy of EBUS-TBNA of mediastinal and hilar ln in PET pos. and neg. cases in suspected malignomas, mainly lung cancer.From 06/2011 to 11/2012, 86 patients underwent EBUS-TBNA. Of these, 39 patients with histologically confirmed malignoma aditionally underwent PET/CT. An average of 1,6 ln (diameter 5 to 20mm), preferably PET pos., were aspirated.If PET/CT was pos. but TBNA neg., subsequent mediastinoscopy was recommended.PET showed pos. mediastinal (n=24) or hilar (n=3) ln in n=27 (69%). In n=21 (78%) PET pos. ln were aspirated and cytology confirmed malignancy in n=16 (76%) (lung cancer n=13, others n=3). TBNA staged down to N0 in n=10 patients (37%). Of those n=4 were confirmed in mediastinoscopy, n=1 all PET-pos. ln had neg. cytology, n=1 thoracotomy staged up to N1 and n=4 remain unclear.PET neg. ln were found in n=12. TBNA showed concordant N0 status in n=10 (83%), in n=2 (17%) EBUS-TBNA staged up to N2. False negative rates are 17%/5% for PET/TBNA respectively and 8% for combination of both.However, one surgery resulted in an incidental N2 status though PET/CT and TBNA indicated N0.Association of staging by PET and EBUS was achieved in 59%/83% for N2/N0. Overall PET/CT correctly diagnosed N status in n=26/39 (67%). EBUS in n= 33/39 (85%).PET guided EBUS-TBNA helps to selectively aspirate lymph nodes but down staging is common in positive PET/CT ln when TBNA is performed. ER -