RT Journal Article
SR Electronic
T1 Community acquired pneumonia, hepcidin and anemia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2717
VO 42
IS Suppl 57
A1 Maria Carrabba
A1 Marina Zarantonello
A1 Lorena Duca
A1 Natascia Campostrini
A1 Alessandra Colombo
A1 Cinzia Hu
A1 Giovanna Fabio
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2717.abstract
AB Pneumonia is an acute inflammation often complicated by the development of anemia. Hepcidin is an IL-6-induced key modulator of inflammation-associated anemia. The association between inflammation, hepcidin and anemia has not been investigated in pneumonia.60 patients were enrolled if admitted out of an infection and serum C-RP ≥3mg/dl. On day 1 (T1) and 6 (T6) serum hepcidin (HEPC), cytokines, inflammation and iron markers were tested. Systemic Inflammatory Response Syndrome and Pneumonia Severity Index (PSI) were assessed at admission.Patients with pneumonia were 27 and 33 patients had other acute infectious diseases. On T1 main findings are showed in figure 1. IL-6 and C-RP concentrations correlated with HEPC levels and the rate of decrease of hemoglobin (Hb) in all patients (r= -0.330, p= 0.009). On T6, both groups lost a Hb mean of 0.5g/dL, but patients with pneumonia were more frequently anemic (77.8%) than the others (48.5%; p=0.032), with an odd ratio of 3.7 for being anemic.According to PSI, 37.0% patients were stratified in the low-risk, 48.2% in the intermediate and 14.8% in the highest-risk-class. Hb loss had a weak negative correlation with PSI score.70.4% of patients with pneumonia and 42.4% of the other group had sepsis. Despite high T1 HEPC mean levels in both groups, only patients with sepsis and pneumonia had a significant Hb decrease between T1 (11.9g/dL) and T6 (11.3g/dL; p=0.013). Patients with pneumonia had an associated 30-day mortality rate of 7.4%, compared to 3% of patients without pneumonia.View this table: