PT - JOURNAL ARTICLE AU - Clara Green AU - Albert Yick Hou Lim TI - Vitamin D level in cystic fibrosis patients with allergic bronchopulmonary aspergillosis and aspergillus sensitization DP - 2013 Sep 01 TA - European Respiratory Journal PG - P1170 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P1170.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P1170.full SO - Eur Respir J2013 Sep 01; 42 AB - Background:Cystic fibrosis (CF) patients have increased risk of developing allergic bronchopulmonary aspergillosis (ABPA). In vitro study showed that Th2 response in ABPA is attenuated by vitamin D3. However, it is not known if there is a correlation of vitamin D level in CF patients with ABPA and aspergillus sensitization (AS).Objectives:To study the vitamin D level in adult CF patients with ABPA and AS.Methods:A retrospective study on all CF patients attending the regional adult CF centre at University Hospital of North Staffordshire. Age, sex, CFTR genotype, BMI, spirometry, sputum microbiology/mycology, Aspergillus serology, spirometric lung functions and vitamin D level were recorded.Results:A total of 65 patients with 97 serum vitamin D level were studied. There were 6 ABPA, 39 aspergillus sensitization and 52 controls. The 3 groups had significant difference (median) in vitamin D3 level (nmol/l) (24, 25, 37, p= 0.011) and vitamin D level (nmol/l) (23, 26, 31, p= 0.024). No differences in vitamin D2 level, FEV1% predicted and BMI. There was a significant correlation between specific IgE to aspergillus fumigatus (AF) RAST score, vitamin D3 and vitamin D level (nmol/l) (D3 level: r=-0.283, p=0.01; D level: r=-0.201, p=0.048).Conclusions:ABPA patients have significant lower level of vitamin D3 and D than patients without. There is a significant negative correlation between specific IgE to AF RAST score, vitamin D3 and D level. This study suggests that vitamin D deficiency is a potential risk factor of developing ABPA and AS.