RT Journal Article
SR Electronic
T1 Smoking status and respiratory infections during mechanical ventilation
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2711
VO 42
IS Suppl 57
A1 Lucas Boeck
A1 Hans Pargger
A1 Peter Schellongowski
A1 Charles-Edouard Luyt
A1 Marco Maggiorini
A1 Maurizio Bernasconi
A1 Kathleen Jahn
A1 Jean Chastre
A1 Rene Lötscher
A1 Evelyne Bucher
A1 Nadine Cueni
A1 Michael Koller
A1 Annekathrin Mehlig
A1 Thomas Staudinger
A1 Heiner Bucher
A1 Michael Tamm
A1 Daiana Stolz
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2711.abstract
AB Background: Smoking is associated with an increased risk of pulmonary infections. However, little is known about smoking history and respiratory infections during mechanical ventilation.Objectives: To assess smoking status in ventilator-associated respiratory infections.Methods: Preliminary data from the multicentric prospective BioVent study, investigating mechanically ventilated critical ill patients, were analysed. Responsible intensivists evaluated the presence of a respiratory infection. Respiratory infections during mechanical ventilation, from 48 hours after start up to 14 days, were assessed.Results: Out of 173 mechanically ventilated patients (mean age 62 ± 16 years; mean duration of mechanical ventilation 8 ± 10 days) 45 patients (26%) never smoked, 61 patients (39%) stopped smoking more than one month before mechanical ventilation and 67 patients (35%) smoked until the month before mechanical ventilation.The time to first respiratory infection was shorter in current smokers as compared to never smokers (p = 0.042) and shorter in former smokers as in never smokers (p = 0.002; figure). There was no difference between current and former smokers (p = 0.30). In cox regression the smoking status was associated with respiratory infection, independent of age, gender, COPD and duration of mechanical ventilation.Conclusions: A smoking history probably increases the risk of respiratory infections during mechanical ventilation.