TY - JOUR T1 - Genetic variation in FCGR2A is associated with increased mortality after lung transplantation JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2684 AU - David Ruttens AU - Stijn Verleden AU - Els Wauters AU - Elly Vandermeulen AU - Robin Vos AU - Dirk Van Raemdonck AU - Diether Lambrechts AU - Bart Vanaudenaerde AU - Geert Verleden Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2684.abstract N2 - Chronic rejection(CR) remains an important problem after lung transplantation (LTx). The immunological pathways in CR remain to be established. Immunoglobulin gamma is involved in rheumatoid arthritis*, disease comparable to CR. The exact role of immunoglobulin gamma for the outcome after LTx has not yet been investigated. We investigated the relationship between genetic variants in the FCGR2A (rs12746613) gene and outcome after LTx.Recipient DNA from blood or explant lung tissue was evaluated for the FCGR2A polymorphism by iPLEX technology on a MassARRAY and paralleled with clinical patient data.FCGR2A was determined in 418 LTx recipients, of which 216 had the CC-genotype (52%), 137 had the CT-genotype (33%) and 65 had the TT-genotype (15%). Univariate analysis demonstrated significant higher mortality in patients with the TT-genotype compared to the CC-genotype, the CT-genotype is showing an intermediary risk.Independent of age, gender, LTx type/time, underlying disease and the use of azithromycin, carriers of the TT variant had an increased risk for mortality (HR: 1.45 CI: [1.177-1.784]; p=0.0005), but not for CR (HR: 1.10 CI: [0.886-1.371] ; p=0.38). The prevalence of acute rejection (p=0.69), lymphocytic bronchiolitis (p=0.30) and infections (p=0.44) were comparable between genotypes.The presence of the TT-genotype of FCGR2A SNP was associated with higher mortality.*Raychaudhuri S, et al. Nat Genet 2009;41:1313-8. ER -