TY - JOUR T1 - The influence of hyperinflation and systemic inflammation on the 6 minute walking distance in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2509 AU - Tadeusz Przybylowski AU - Renata Rubinsztajn AU - Marta Maskey-Warzechowska AU - Magdalena Paplinska-Goryca AU - Patrycja Nejman-Gryz AU - Krzysztof Karwat AU - Ryszarda Chazan Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2509.abstract N2 - Dyspnea and impaired exercise tolerance are frequent in patients with COPD. Hyperinflation contributes to exercise intolerance by its negative impact on lung mechanics.Aim: to evaluate the influence of hyperinflation on the 6 minute walking distance and the markers of systemic inflammation in patients with COPD.The study group consisted of 149 patients with stable COPD (61F, 88M) aged 68±8.8 yrs.All the patients underwent spirometry and bodypletysmography with bronchial reversibility testing and 6 minute walking test (6MWT). Hyperinflation was defined as RV%TLC > 48% and > 126% predicted. The following serum inflammatory markers were evaluated: C-reactive protein, IL-6, IL-8, TNF alpha, CC16, adiponectin and resistin.The patients were divided into group A (patients without hyperinflation, n=53) and group B (patients with hyperinflation, n=96). Table 1 presents significant differences in the results of the 6 MWT between the two groups.View this table:Table 1We found significant positive correlations between 6 MWD and serum IL-8 (R=-0.2,p=0.02), IL-6 (R=-0.3, p=0.002), TNF alpha (R=-0.2, p=0.04) and C-reactive protein (R=-0.2, p=0.03); SpO2 6 min and resistine (R=0.2, p=0.006), CC16 (R=0.2, p=0.03); RV%TLC and IL6 (R=0.2, p=0.007) in the group as a whole.Conclusions:1/ Hyperinflation has a negative influence on exercise tolerance in COPD patients.2/Systemic inflammation may also deteriorate exercise tolerance in COPD patients. ER -