RT Journal Article SR Electronic T1 Prognostic significance of 6-minute walk test in non-group 1 pulmonary hypertension JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2611 VO 42 IS Suppl 57 A1 Rafael Golpe A1 Olalla Castro-Añón A1 Luis A. Pérez de Llano A1 Carlos González-Juanatey A1 María C. Muñiz-Fernández A1 Ana Testa-Fernández A1 Ruth Pérez-Fernández YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2611.abstract AB Background: Distance walked during six-minute walk test (6MWT) correlates strongly with mortality in idiopathic pulmonary arterial hypertension; however it might be a less accurate predictor of outcome in associated pulmonary hypertension (PH). Our objectives were to assess the value of variables obtained during 6MWT and echocardiography to predict outcome in non idiopathic PH.Methods: 6MWT and echocardiography were performed in 60 patients diagnosed of PH, Dana Point classification groups 2 to 5. Kaplan-Meier cumulative survival plots and Cox proportional hazards regression models were used to evaluate hazard ratios for study variables.Results: Patients who died had more frequently right ventricle (RV) systolic function depression, RV dilatation, and walked less distance during the 6MWT. The mortality ratio for patients with RV systolic function depression, RV dilatation, and distance walked < 400 m were 4.81 (95%CI: 2.27-67.01), 12.61 (95% CI: 2.05-22.47) and 4.28 (95% CI: 1.04-11.25), respectively. On multivariate analysis, only RV systolic function depression and distance walked on 6MWT independently predicted mortality.Conclusion: the study confirms the value of 6MWT to predict prognosis in non-group 1 PH and suggests that this test should be considered in the integral clinical evaluation of patients with this disorder.