TY - JOUR T1 - Symptom profile of exacerbations in earlier and later COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 3044 AU - James Allinson AU - Gavin Donaldson AU - Anant Patel AU - Beverly Kowlessar AU - Alex Mackay AU - Richa Singh AU - Simon Brill AU - Jadwiga Wedzicha Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/3044.abstract N2 - Characterising exacerbations in early COPD may identify targets to modify disease trajectory. We investigated if exacerbation characteristics differ between “earlier”(FEV1>60%predicted) and “later”(FEV1<60%predicted) COPD.Daily symptom diary card and clinic visit data were prospectively collected for 211 patients in the London COPD Cohort over seven years. Exacerbations were defined as previously(Seemungal 2000).View this table:Table1:Spirometry & exacerbation rates of earlier & later COPD groupsThe earlier group (n=63;56 with≥1exacerbation) had fewer exacerbations(Table1) and reported more cold and sore throat symptoms than the later group (n=148;136 with≥1exacerbation)(Table2&Fig1). Demographics, active smoking and chronic bronchitis were similar between groups.View this table:Table2:Exacerbation symptoms in earlier and later COPD groupsHigher prevalence of viral symptoms at exacerbation in earlier COPD suggests differences in viral susceptibility compared to later COPD. ER -