TY - JOUR T1 - Influence of fungal colonization on 6-minute-walk test disance in patients with hypersensitivity pneumonitis JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2181 AU - Ilya Sivokozov AU - Olga Lovacheva AU - Elena Shergina AU - Natalya Makaryants AU - Eugene Shmelev Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2181.abstract N2 - Background. Fungal antigens sensibilization is a known cause of hypersensitivity pneumonitis (HP). Nevertheless, the role of fungal colonization in respiratory tract on clinics and prognosis of HP is still unclear.Aim. To assess the influense of fungal colonization on excercise tolerance in HP.Methods. 79 pts with morphologically proven HP were enrolled. Mean age 48,8 yrs, males 33. In all cases during work-up BAL was performed with PCR test on DNA of Aspergillus and Candida fungi, as also as PFT and 6MWT. Data were analyzed using Mann-Whitney test.Results. Fungi were detected in 21/79 (27%) pts. The were no difference between PCR-positive and negative groups for Aspergillus in PFT, but there was significant difference for sPO2 before and after 6MWT (94,1 and 90 %; 91 and 88% respectively, p<0.05), as also as more prominent fatigue on Borg scale (2,9 and 3,9; 5,3 and 6,5 points, respectively p<0.05). There was a trend to lower walking distance in PCR-positive patients vs controls (380 and 344 m, respectively, p>0.05). Detection of Candida in BAL did not impact on HP.Conclusion. Fungal colonization with Aspergillus worsens excercise tolerance in HP patients, whereas Candida doesn't impact on HP. ER -