PT  - JOURNAL ARTICLE
AU  - Eylem Özgür
AU  - Sibel Atis Nayci
AU  - Cengiz Özge
AU  - Yasin Duman
AU  - Gamze Çavusoglu
AU  - Ahmet Ilvan
TI  - The relation of comorbidities with the exacerbation severity in patients with COPD
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2144
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2144.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2144.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Comorbidities are common in patients with COPD, but there is a few study investigating the relation of comorbidities with the exacerbation. We aimed to compare the comorbidities according to exacerbation severity in COPD patients.We recruited 157 COPD patients. They were divided into four groups according to exacerbation severity: patients hospitalized in ICU(n=21,group 1), patients hospitalized in the pulmonary service(n=51, group 2), patients with non-hospitalized(n=42, group 3), and without exacerbation in the previous year(n=43, group 4).Mean FEV1 46.3±17.27%, and Charlson score 1.87±1.38. The most frequent comorbidities were: hypertension (43.3%), ischemic heart disease (29.3%), diabetes (17.2%), chronic heart failure(17.8%), cachexia(15.9%), obesity(25.5%), anemia(12.7%), dyslipidemia (19.7%), chronic kidney disease (10.8%), and depression (11.5%). The patients of hospitalized in ICU had higher charlson score(2.4 vs. 2.1, 1.3, 1.8 respectively; p=0.007) than the other groups. This group had a greater proportion of cor-pulmonale(100% vs 72.5%, 7.1%, 20.9%, p<0.0001), diabetes (38.1% vs. 23.5 %, 7.1%, 9.3%, p=0.005), cachexia (41.2% vs. 19.5%, 19%, 4.7%, p=0.008), anemia(28.6% vs. 15.7%, 4.9%, 9.3%, p=0.05) and OSAS (19.5% vs. 5.9%, 0%, 3.7%, p=0.001) compared to the other groups. Group 2 had a higher rate of chronic heart failure(28.6% vs. 2.4%, 8.6%, p=0.01) and atrial fibrillation(16.3% vs. 0%, 4.7%; p=0.026) than patients of group 3 and 4.In conclusion, this study showed that higher incidence and more severe degree of respiratory and other comorbidities in COPD patients with severe exacerbation. It was thought that comorbidities contribute to the severity of exacerbation in COPD patients.