TY - JOUR T1 - Dynamic of adherence to guidelines for antibiotic therapy of community-aquired pneumonia (CAP) JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2734 AU - Hanna Demchuk AU - Yuriy Mostovoy Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2734.abstract N2 - To estimate in dynamic correspondence to national guidelines introduced in 2003 and 2007and efficacy of antibiotics (A) prescription for treatment of patients with CAP comparative analysis of A therapy of 158 inpatients (Pt) treated in 2006 (Gr1) and 153 Pt treated in 2012 (Gr2) was performed. In Gr1 average age of Pt was 48,5±18,4 years old, 81(51,3%) were male. In Gr2 average age of Pt was 55,4±16,5 years old, 65 (42,5%) were male. Most of Pt of both groups treated with recommended A, but in Gr2 this index was higher than in Gr1 – 140 (91,5%) Pt and 108 (68,4%) Pt, agreeably (p<0,001). The most frequently prescribed A in the both groups were cephalosporines III generation with macrolides at 71 (44,9%)Pt of Gr1 and at 35 (22,9%) Pt of Gr2. More than one third (35,9%) Pt of Gr2 received cephalosporines III generation+levofloxacin (p<0,05). Combination of amoxicillin/klavulanates+macrolides more frequently prescribed at Gr1 (32 (20,2%)Pt), than in Gr2 (14 (9,2%)Pt) (p<0,05). Levofloxacin only was used by 25 (16,3% )Pt of Gr2, but any Pt of Gr1 did not received this A. Incorrect A prescription in the both groups included error combinations of A at 32 (22,9%) Pt of Gr1 and 13 (8,5%)Pt of Gr2 (p<0,001). At Gr1 “classic” fluoroquinolones, cephalosporines I generations, amikacin were prescribed but not recommended for CAP therapy. Higher adherence to guidelines in Gr2 resulted in higher efficacy of treatment: complete or partial recovery was at 145 (91.8%) Pt of Gr1 and 141 (92,2%) at Gr2, 4(2,5%) Pt of Gr 1 were died, but all Pt of Gr2 survived. Thus during 6 years adherence to prescription of A accordance with guidelines increased on 29,6%. It is improve outcome of CAP. ER -