TY - JOUR T1 - Lipid profile in COPD patients with coronary artery disease comorbidity JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1865 AU - Olena Krakhmalova AU - Olena Hetman Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1865.abstract N2 - Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are global epidemics that incur significant morbidity and mortality. Both conditions are systemic disorders with overlapping pathophysiologic mechanisms and risk factors.Aim: To investigate the levels of total cholesterol (TCH), triglycerides (TG), low density lipoproteins (LDL), very low density lipoproteins (VLDL), high density lipoproteins (HDL) in COPD patients with and without CAD as a risk factors of cardiovascular death.Method: 88 COPD patients ((mean±SD) - 59 males (60,5%) mean age 62,3±14,5 years, FEV1: 52±15 % pred., BMI: 28,2±5,4 kg/m2 with stable COPD participated in the study. We compared lipid profile in 48 patients with COPD and verified stable angina II-III WHO’s functional class and control group - 40 COPD patients without CAD.Results: Mean LDL concentration among cases was 114.89 ± 19.61(mg/dl) as against control group who had mean LDL concentration of 96.22 ± 19.96(mg/dl), which was statistically significant (p-value < 0.05). However no significant difference in VLDL, HDL and in triglycerides levels were observed. Mean LDL concentration strongly correlated FEV1 lowering in COPD and CAD group (r= -0,485, p=0,006). In control group (isolated COPD) there were no significant correlation between LDL levels and FEV1.Conclusion: Increased LDL cholesterol in patients with a higher degree of bronchial obstruction indicates a more aggressive course of atherosclerosis in chronic hypoxia. Thus, in patients concomitant cardiopulmonary disorders increases the risk of cardiovascular complications. ER -