PT  - JOURNAL ARTICLE
AU  - Felix Horn
AU  - Helen Marshall
AU  - David Barber
AU  - Juan Parra-Robles
AU  - David Lipson
AU  - Rod Lawson
AU  - Jim Wild
TI  - Bronchodilator treatment response mapping in COPD using hyperpolarised gas ventilation MRI
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - 3027
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/3027.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/3027.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Lung imaging using hyperpolarised ³He gas MRI (HP-MRI) [ Wild J., et al., Mag. Reson. in Medicine 2002; 47:687-95] is able to regionally resolve changes in lung ventilation in response to therapy in obstructive airways diseases such as COPD.A novel way to quantitatively map regional treatment response with ventilation difference mapping of the lungs of patients pre- and post-therapy using HP-MRI was designed and evaluated.The method was tested with COPD patient datasets. Ventilation images were acquired using HP-MRI; A baseline scan before application of standard prescription bronchodilator and one after. The post treatment datasets were registered [ Barber D.C. et al., Medical image analysis 2007; 11:648-62] to the baseline image and segmented. All datasets were normalised and smoothed. The treatment response map was generated as the difference between baseline and post treatment image.Figure 1(G) shows the treatment response map of a COPD patient. Green represents increased ventilation post bronchodilator, red areas show a decrease in ventilation. This method enables a direct mapping of ventilation changes pre and post-treatment.Treatment response mapping provides a novel way to quantify and visualise regional differences in lung ventilation pre- and post-treatment as shown here in a COPD patient dataset.Funding by EU FP7 Airprom & PInetGSK Study RES111175 is also acknowledged as a co-sponsor of this research.