RT Journal Article
SR Electronic
T1 Viral etiology, disease severity and treatment effect in acute bronchiolitis in South-Eastern Norway
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 5011
VO 42
IS Suppl 57
A1 Håvard Ove Skjerven
A1 Spyridon Megremis
A1 Nikolaos G. Papadopoulus
A1 Kai-Håkon Carlsen
A1 Karin C. Lødrup Carlsen
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/5011.abstract
AB Background:Acute bronchiolitis is a frequent cause of hospitalization in infants worldwide. The etiology is predominantly viral, occurring in seasonal patterns, with Respiratory Syncytial Virus (RSV) as the most common. Inhaled adrenaline (iRA) is a commonly used treatment. The influence of viral etiology on treatment effect and disease severity is not clear.Aims:We aimed to assess the association between viral etiology and 1) disease severity and 2) treatment effect with inhaled adrenaline.Methods:In a RCT of bronchiolitis treatment (Bronchiolitis ALL-SE Study) assessing medication (iRAvs saline(iNS)) and strategy (on demand(OD) versus fixed schedule(FS))(Figure below), nasopharynx aspirate of 363/404 patients (mean age 4.2 months, 60% boys) were analyzed with modern sensitive viral detection techniques. Associations between etiology (virus type and number of simultaneous viruses detected in each individual) and measures of disease severity (length of hospital stay, use of supportive care, clinical score, SpO2 and respiratory frequency) were analyzed by regression analyses. The impact of viral etiology (number of simultaneous viruses and subgroups) on the effect of treatment were assessed by interaction analyses.Results and conclusion:The types of virus detected or the number of simultaneous viruses found were not significantly associated with disease severity nor did they interact treatment efficacy.