PT  - JOURNAL ARTICLE
AU  - Prasad Nagakumar
AU  - Jyotsna Vaswani
AU  - Julian Forton
AU  - Iolo Doull
TI  - Temporal changes in the prevalence of respiratory pathogens in children and adolescents with cystic fibrosis (CF)
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3378
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3378.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3378.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: Changes in the prevalence of respiratory pathogens in CF may reflect improved therapeutic strategies and clinical practice within a CF centre.Aims: We hypothesized that active microbiological surveillance and a low threshold for long term nebulised antibiotics might reduce the prevalence of respiratory pathogens in patients with CF.Methods: Retrospective review of data of patients under full care at a paediatric CF centre in Cardiff between 1998(n=80) and 2011(n=70). We calculated the number of isolates for common pathogens from 1998 onward (expressed as a percentage for each year); mean number of respiratory cultures taken for each patient per year; and the rate of chronic P aeruginosa (Lee 2003) from 2002 onward. Changes in prevalence over time were assesed by linear regression.Results:Non-significant increase in mean (SD) number of respiratory cultures from 5.3(3.22) to 7.4(2.89) per patient/year.The prevalence of P aeruginosa infection decreased significantly from 43.8% in 1998 to 14% in 2011(r= -0.80, p=0.001), while chronic P aeruginosa infection decreased from 19% in 2002 to 2.9% in 2011(r=-0.92, p< 0.0001) .We also observed significant decreases in the prevalence of A fumigatus (r=-0.92, p<0.0001), H influenzae (r=-0.58, p=0.03) and B Cepacia (r=-0.78 p=0.001), and a non-significant reduction in the prevalence of S Aureus with non-significant increases in the prevalence of S maltophilia or MRSA.Conclusion: Active microbiological surveillance and a low threshold for long term nebulised antibiotics was associated with significant reductions in both the prevalence of P aeruginosa infection and the rate of chronic P aeruginosa infection.