TY - JOUR T1 - Effect of aclidinium bromide on static lung function and hyperinflation in patients with moderate to severe COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 4633 AU - Henrik Watz AU - Kai M. Beeh AU - Helgo Magnussen AU - Luis de Theresa AU - Diana Jarreta AU - Cynthia Caracta AU - Esther Garcia Gil Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/4633.abstract N2 - INTRODUCTION: Improvements in static lung mechanics and hyperinflation are important therapeutic goals in COPD.AIMS: To investigate the effects of aclidinium on static lung function and hyperinflation in patients with COPD.METHODS: This double-blind, randomized, crossover study compared aclidinium bromide 400 µg BID (metered dose; equivalent to aclidinium 322 µg BID delivered dose) with placebo, each for 3 weeks, in 112 patients with moderate to severe COPD (FEV1 1.50 L, 56.7% pred). Efficacy variables included: change from baseline in trough inspiratory capacity (IC), FEV1 and IC/total lung capacity (TLC); trough and 2-hour post-dose functional residual capacity (FRC), residual volume (RV), and specific airway conductance (sGaw); and 2-hour post-dose TLC.RESULTS: see table.View this table:Change from baseline (adjusted LS mean [95% CI]) and treatment difference at Week 3CONCLUSIONS: Aclidinium significantly improved static lung hyperinflation in COPD patients. ER -