@article {SalhiP5070, author = {B. Salhi and C. Haenebalcke and S. Perez-Bogerd and D.M. Nguyen Dang and R. Colman and K.Y. Vermaelen and T.L. Malfait and V.F. Surmont and G. Van Maele and V. Ninane and J.P. van Meerbeeck and E. Derom}, title = {Effect of resistance training (RT) on maximal exercise capacity (MEC) and muscle force (MF) in patients (pts) with radically treated (RaT) intrathoracic cancer}, volume = {42}, number = {Suppl 57}, elocation-id = {P5070}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Introduction: We recently reported in pts with intrathoracic cancer that 12w of RT significantly improves the 6MWD to pre-RaT-values. (Salhi B, ATS 2013, ID 40574).Aim: To estimate the effect of 2 RT-programs on MEC and MF, as estimated by the maximal workload (Wmax) and quadriceps force (QF).Methods: Eligible pts were randomly allocated after completion of RaT, to either a conventional RT (CRT), RT by whole-body-vibration (WBV) or usual care (UC). Wmax and QF were assessed before RaT (M1), at randomisation (M2) and 12w thereafter (M3). An increase of 10 Watt in Wmax was considered the minimal change of interest. Descriptives are presented as medians. Changes over time were analyzed by a linear regression model and presented as means with 95\% CI. Results: 70 patients were randomized: 73\% male; 62 y (29-79). 91\% had NSCLC; 40\% COPD; 48\% underwent surgery and 6\% radiotherapy as sole therapy, 46\% had a combination of at least 2 modalities. M2-M3 interval was 14w (9-30). Pts attended 28 CRT- (10-36) and 23 WBV-sessions (0-37). M2-M3 change in Wmax is 15 W (6{\textendash}24) with both CRT and WBV (p= 0.002), but not significantly different with the 7 W (-2{\textendash}17) change after UC (CRT vs UC p=0.22; WBV vs UC p= 0.23). The M3-M1 gap in Wmax remained significant with UC only (p =0.005). M2-M3 change in QF is 9 Nm with both WBV (-6{\textendash}23) (p= 0.24) and UC (-4{\textendash}23) (p= 0.20) and 23 Nm (10{\textendash}36) with CRT (p= 0.0009), but was not significantly different between CRT and UC (p= 0.13).Conclusion: Both CRT and WBV significantly improve post-RaT MEC, whilst MF is only improved by CRT. MEC does not recover to pre-RaT values with 12w UC.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P5070}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P5070.full.pdf}, journal = {European Respiratory Journal} }