RT Journal Article
SR Electronic
T1 A comparison of multi-component indices of COPD severity in primary care: An UNLOCK study from the IPCRG
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2006
VO 42
IS Suppl 57
A1 Rupert Jones
A1 David Price
A1 Niels Chavannes
A1 Amanda Lee
A1 Elizabeth Gabe-Thomas
A1 Bjorn Stallberg
A1 Karin Lisspers
A1 Josefin Sundh
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/2006.abstract
AB Objective: To compare the DOSE and ADO indices with a range of outcomes across multiple COPD populations, as gauges of COPD severity.Design: Real-life observational cohort study.Study population: 5486 primary care COPD patients : 4400 in the Optimal Patient Care database; 370 in Devon UK; 154 in a pulmonary rehabilitation programme rehabilitation in Holland; 562 in PRAXIS-study, Sweden.Main outcome measures: DOSE and ADO associations with CCQ and SGRQ; current and future exacerbations and hospital admissions and mortality.Results: Both DOSE and ADO indices inversely correlated with CCQ and SGRQ (p<0.001), DOSE was stronger across all items and with healthcare consumption markers (treatment-defined exacerbations, out of hours general practitioner visits and hospital admissions). DOSE, but not ADO, predicted future exacerbations and admissions. Both indices predicted mortality, ADO was the stronger of the two.View this table:Table 1: Rank correlations of DOSE and ADO indices with health status, exacerbations and future hospital admissionsConclusions: The DOSE index is better than the ADO index for predicting a wide range of outcomes in a diversity of COPD patients. The DOSE index is suitable a tool in routine clinical practice to identify those with current symptoms and future risk of exacerbations, admissions and mortality.