RT Journal Article
SR Electronic
T1 Predictors of lipoprotein particle size and subclasses in patients with OSA
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3051
VO 42
IS Suppl 57
A1 Radovan Tisko
A1 Zorana Jelic-Ivanovic
A1 Viera Habalova
A1 Zuzana Sopkova
A1 Eva Slaba
A1 Jelena Vekic
A1 Zuzana Dorkova
A1 Aleksandra Zeljkovic
A1 Pavol Joppa
A1 Manfredi Rizzo
A1 Ruzena Tkacova
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/3051.abstract
AB Rationale: Apolipoprotein E (APOE) gene polymorphism is related to atherogenic dyslipidemia, and may play a role in affecting low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) size and subclasses distribution. Importantly, intermittent hypoxia increases serum lipids in APOE-deficient mice. Previously we have demonstrated atherogenic dyslipidemia and reduced LDL size in patients with obstructive sleep apnea (OSA). Here we aimed to analyze the effects of APOE gene polymorphisms on LDL and HDL size and subclasses in patients with OSA.Methods: 189 adult subjects underwent full overnight polysomnography. The association of HDL-C and LDL-C size and subclasses with apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and arousal index, and with APOE gene polymorphism was examined and adjusted for relevant covariates.Findings: Patients were 61.4% male (age 51.7±12.0 years, AHI 29.5±30.1 events/hour). LDL-C size was related to APOE polymorphism (p=0.024), due to a reduction in large LDI-I particles and increase in small dense LDL-IVB particles. In addition, LDL-C size was related to ODI, AHI and arousal index in univariate analyses (r=-0.136, p=0.028; r=-0.172, p=0.005; r=-0.132, p=0.032; respectively). In contrast, HDL-C size was related to AHI only (r= 0.137, p=0.026). In multivariate analysis, only APOE genotype predicted LDL-C size independently of age, gender, body mass index and severity of OSA (R2=0.095, p=0.013).Conclusion: Our results suggest relationships between APOE gene polymorphism and LDL-C size in patients with OSA. Further studies are needed to evaluate clinical implications of present findings.Funding: APVV-0134-11, VEGA 1/0111/12, Slovakia.