TY - JOUR T1 - Is COPD a risk factor for diabetes? JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P542 AU - Laura Ciobanu AU - Vasile Maciuc AU - Anca Cretu AU - Gabriela Grigoras Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P542.abstract N2 - Introduction: Diabetes mellitus is one of the multiple endocrinological disorders induced by COPD through systemic inflammation, oxidative stress, smoking and administration of glucocorticoids.Aims and objectives: To investigate if COPD is a risk factor for diabetes mellitus DM and what stage is more risky; also, if there are some other contributing factors.Methods: 2 groups of pts were assessed for age, gender, body mass index (BMI), smoking, alcohol intake, diabetes and dyslipidemia. First group was compound of non-COPD pts (N 272, 62 M/22.8%, 210 F/77.2%, mean age 60.67, SD 13.75) and the second one of COPD pts (N 178, 103 M/57.9%, 75 F/42.1%, mean age 64.79, SD 10.78). COPD pts were staged according to GOLD criteria in stage I 122/27.1 % pts, stage II 28/6.2 % pts, stage III 22/4.9% and stage IV 6/1.3%.Results: The relative risk RR for DM to appear in COPD pts is 1.380 (95% CI 1.054-1.806). RR is 1.023 (95% CI 0.896-1.146) in COPD stage I, 1.252 (95% CI 0,904-1.735) in stage II and 2.062 (95% CI 0.863-4.930) in unified stages III and IV. There is a correlation coefficient R of 0.154 between COPD and DM, 0.256 for COPD, BMI and DM and respectively 0.293 for COPD, BMI, dyslipidemia and DM.Conclusions: There is a small risk for DM to appear in the whole group of COPD pts, but RR increases while advancing the severity of disease. Being mild in stages I and II, RR become moderate in the unified group of pts staged III and IV, considered together due to the low number for each separate stage. Correlation between DM and COPD is weak, but it is moderate and relevant when adding BMI and dyslipidemia. The risk to develop DM in COPD increases with the severity of disease, and the presence of two other important factors, BMI and dyslipidemia. ER -