RT Journal Article
SR Electronic
T1 Prognostic predictors in younger and older incident idiopathic pulmonary arterial hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4837
VO 42
IS Suppl 57
A1 Yi Ling
A1 Martin Johnson
A1 David Kiely
A1 Robin Condliffe
A1 Charlie Elliot
A1 J. Simon R. Gibbs
A1 Luke Howard
A1 Joanna Pepke-Zaba
A1 Karen Sheares
A1 Paul Corris
A1 Andrew Fisher
A1 Jim Lordan
A1 Sean Gaine
A1 J. Gerry Coghlan
A1 S. John Wort
A1 Michael Gatzoulis
A1 Andrew Peacock
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/4837.abstract
AB Background:We have recently shown that there are important phenotypic and survival differences between younger and older incident idiopathic pulmonary arterial hypertension patients (Ling et al, AJRCCM 2012;186:790-6). We sought to establish whether there are different prognostic associations between the two groups.Methods:Observational study of all incident idiopathic, heritable and anorexigen-associated pulmonary arterial hypertension diagnosed in all 8 pulmonary hypertension centres in the UK and Ireland between 2001-9 (n=482). Patients were divided into younger (age ≤50) and older (age>50) subgroups by the median age. Demographic and physiological data at diagnosis were analysed by multivariate Cox regression to determine independent predictors of survival.Results:View this table:Predictors of survival according to age subgroupsConclusion:While we have shown that younger and older patients with idiopathic pulmonary arterial hypertension have different characteristics and survival, here we show that there may also be some different associations with survival between the two groups which merit further evaluation.