TY - JOUR T1 - Influence of statin treatment on cancer mortality in COPD patients: Retrospective observational cohort study JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P997 AU - Perrine Crequit AU - Isabella Annesi Maesano AU - Christos Chouaid AU - Gilles Hejblum Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P997.abstract N2 - Background:The anti-inflammatory and immunomodulatory statin properties have been suggested for preventing cancer development in patients with Chronic Obstructive Pulmonary Disease (COPD). However, the effect of statin on cancer mortality in COPD patients is poorly documented. The study endpoint is to evaluate the impact of statin on cancer mortality of COPD patients.Methods:Based on a large pharmaceutical French database of the North area, a retrospective cohort study was conducted in order to evaluate the effect of statin on cancer mortality in COPD patients. Analysis, based on a Cox proportional hazards model with statin exposure handled as a time-dependent variable, included the 66 429 individuals 40 years old or more who had at least one pharmaceutical dispensation between 01/01/2000 and 05/11/2007. In this cohort, 9531 COPD patients were identified; 18.1% of COPD patients were considered exposed to statin.Findings:The overall death rate of COPD patients is 40.8%. The various causes accountable for COPD patients' death were: cardiovascular diseases for 33.7%, respiratory diseases for 33.7% and cancer for 24.8%. Statin treatment was significantly associated with a decrease of cancer mortality in COPD patients with estimates (hazard ratio [95% CI], p value) at 0.586 [0.465-0.739], p=<0.0001.Interpretation:It seems that statin delivery to COPD patient reduces the cancer death rate. However the result has to be checked out by prospective randomized studies. ER -