TY - JOUR T1 - BALF TNFα level in relation to inflammatory status and phenotype of sarcoidosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P698 AU - Anna Goljan Geremek AU - Michal Bednarek AU - Elzbieta Puscinska AU - Monika Czystowska AU - Monika Franczuk AU - Iwona Bestry AU - Malgorzata Filewska AU - Marek Kram AU - Urszula Demkow AU - Dorota Górecka Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P698.abstract N2 - Determining the inflammatory status of the disease may be helpful in predicting the prognosis and responsiveness to treatment.Aim: To evaluate the relation of BALF TNFα levels to the inflammatory status and phenotype of sarcoidosis.Material and methodsWe have measured: TNFα, TGFβ,IL2, IL2R, IL12, IL10 in BALF and TNFα, TGFβ,IL2, IL12, IL10 levels in serum in 184 sarcoid patients.We checked for the correlations between BALF TNFalpha and cytokines, selected systemic inflammatory markers and clinical factors (age, duration of the disease, PFT, 6MWT, extrapulmonary involvement).ResultsWe have found important positive correlation between concentration of BALF TNFα and:- BALF: IL2R(r=0,4676, p=0,0001), IL12 (r=0,4545, p=0,0001) and serum: IL12 (r=0,26, p=0,001), IL10 (r=0,2832, p=0,001), TNFα (r=0,1871, p=0,12).- serum CRP(r=0,2427, p=0,003), γglobulins(r=0,1648, p=0,033), Ddimers(r=0,1685, p=0,035).- the age of patients (r=0,16, p=0,029),No relation was found between the BALF TNF alpha and the duration of the disease, PFT (except for FEV1 r=-0,1464, p=0,05), 6MWT, extrapulmonary sarcoidosis (liver and spleen dimensions, hepatic enzymes, protrombine), Ca and P serum nor urine levels. Weak but important negative correlation was observed between BALF TNFα and monocytosis(r=-0,1788, p=0,015).ConclusionIn our group of patients:The BALF cytokine inflammatory status reflects the systemic inflammation (measured by the serum cytokine network and non-specific inflammatory biomarkers).The BALF TNFα status has no relation to the phenotype of sarcoidosis. ER -