RT Journal Article
SR Electronic
T1 Aerosol deposition during acute bronchoconstriction studied by synchrotron radiation imaging in rabbits
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 208
VO 42
IS Suppl 57
A1 Sam Bayat
A1 Loïc Dégrugilliers
A1 Gergely Albu
A1 Liisa Porra
A1 Ferenc Petak
A1 Satu Strengell
A1 Pekka Suortti
A1 Anssi Sovijarvi
A1 Walid Habre
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/208.abstract
AB RATIONALE: We assessed the effect of acute bronchoconstriction on regional aerosol deposition in the lungs of anaesthetized rabbits.METHODS: We used K-edge subtraction synchrotron imaging (KES), to quantify the deposition of iodine-containing aerosol (Iomeprol 88 mg/ml in NaCl 0.9%, MMAD: 2.6±0.1 µm), in control and methacholine-challenged (Mch, 10 µg/kg/min IV) anaesthetized rabbits (Wt=2.9±0.1 kg) on pressure-controlled ventilation. Iodine deposition maps were obtained in 30 contiguous images after 5 minutes of nebulization. Airway (Raw) and tissue resistance (G) and elastance (H) were measured using forced oscillation technique.RESULTS: Iodine deposition showed significant heterogeneity (Figure) in both groups. Total iodine deposition was reduced in the Mch group, as well as tidal volume, with a significant correlation between the 2 parameters (R=0.83, p<10-6).View this table:CONCLUSIONS: KES imaging offers a unique tool for the measurement of regional aerosol deposition in vivo. These data highlight the relation between ventilation pattern and regional aerosol deposition, during acute bronchoconstriction under mechanical ventilation.