TY - JOUR T1 - Lipid laden macrophages and lipase as markers of aspiration in patients with chronic cough JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P809 AU - Begoña Palomo AU - José Belda AU - Miguel Arias AU - Almudena García AU - Francisco R. Jeréz AU - Nuria Zapico AU - Susana Magáz AU - C.J. Rodríguez Pandiella AU - Socorro Braga AU - Pere Casan Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P809.abstract N2 - Introduction: Gastroesophageal reflux disease (GERD) causes chronic cough by several mechanisms such as reapeated microaspiration.Some authors question that IL exclusively reflects this phenomenon.Our aim was to evaluate the lipase as a marker of microaspiration.Material and methods: We included 79 patients with chronic cough who underwent of clinical history, spirometry with bronchodilator test, chest radiography, determination LI in sputum and measurement of lipase in blood and sputum.Results: We obtained 77 samples of sputum with cellurarity enough and 42(54%) had lipid laden. The average LI was 110. In 55 patients(71%) blood lipase (36 (16)U / L) and sputum (14 (35) U / L) could be determined. But there was no significant correlation between them. Lipase in sputum was not associated with LI, although patients with LI> 30 had higher levels of lipase. Patients with symptoms of reflux had LI and lipase higher in sputum than patients without clinical reflux (mean difference of 26 units (p = 0.03) and 9 U/L (0.001), respectively). Also, patients taking proton pump inhibitors (PPIs) had not lower LI and lipase levels in sputum.Patients with a LI> 30 had lower FVC (mean difference 533ml, p = 0.033) and FEV1(mean difference 507 ml, p = 0.019) and an inverse relationship between LI and lung function when adjusted for the presence of asthma that is not could be confirmed for the lipase.Conclusions: Lipase in sputum is detectable in most patients with chronic cough.Patients with clinical reflux have higher levels of both markers, but therapy with PPIs modifies the results.Elevated IL affects lung function. ER -