RT Journal Article
SR Electronic
T1 Heart failure with preserved ejection fraction in patients with chronic obstructive pulmonary disease exacerbation is associated with poor long-term survival
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3348
VO 42
IS Suppl 57
A1 Robert Marcun
A1 Ivan Stankovic
A1 Jerneja Farkas
A1 Alja Vlahovic
A1 Biljana Putnikovic
A1 Sasa Kadivec
A1 Mitja Kosnik
A1 Alekandar Neskovic
A1 Mitja Lainscak
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3348.abstract
AB Background: Diagnosing heart failure with preserved ejection fraction (HFPEF) in patients with chronic obstructive pulmonary disease (COPD) is difficult due to overlapping symptoms and signs. We sought to identify the prevalence and prognostic implications of HFPEF in patients hospitalized for COPD exacerbation.Methods: A total of 119 consecutive patients (70±10 years, 68% men) with acute exacerbation of COPD were included in the study. The diagnosis of HFPEF was made according to the consensus statement of the European Society of Cardiology. Patients were followed for 22±9 months and all-cause mortality was analyzed.Results: HFPEF was diagnosed in 23 (19%) patients, who were older (75±10 vs. 69±10 years; p=0.013), and more frequently had arterial hypertension (65 vs. 37%; p=0.018) and atrial fibrillation (48 vs. 8%; p<0.001). They also had higher LV end-diastolic dimension (53±7 vs. 50±4 mm; p=0.009), LV mass (114±27 vs. 98±20 g/m2; p<0.001), left atrial size (47±7 vs. 38±6 mm; p<0.001), mitral E/Ea ratio (12.5±7 vs. 9.1±2.5; p=0.035) and the basal right ventricular end-diastolic dimension (39±8 vs. 31±5 mm; p<0.001) than those without HFPEF. HFPEF and increasing mitral E/Ea ratio was associated with increased mortality (Figure).Conclusions: HFPEF was present in 19% of COPD patients and is associated with poor long-term survival.