PT  - JOURNAL ARTICLE
AU  - Robert Marcun
AU  - Ivan Stankovic
AU  - Jerneja Farkas
AU  - Alja Vlahovic
AU  - Biljana Putnikovic
AU  - Sasa Kadivec
AU  - Mitja Kosnik
AU  - Alekandar Neskovic
AU  - Mitja Lainscak
TI  - Heart failure with preserved ejection fraction in patients with chronic obstructive pulmonary disease exacerbation is associated with poor long-term survival
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P3348
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P3348.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P3348.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: Diagnosing heart failure with preserved ejection fraction (HFPEF) in patients with chronic obstructive pulmonary disease (COPD) is difficult due to overlapping symptoms and signs. We sought to identify the prevalence and prognostic implications of HFPEF in patients hospitalized for COPD exacerbation.Methods: A total of 119 consecutive patients (70±10 years, 68% men) with acute exacerbation of COPD were included in the study. The diagnosis of HFPEF was made according to the consensus statement of the European Society of Cardiology. Patients were followed for 22±9 months and all-cause mortality was analyzed.Results: HFPEF was diagnosed in 23 (19%) patients, who were older (75±10 vs. 69±10 years; p=0.013), and more frequently had arterial hypertension (65 vs. 37%; p=0.018) and atrial fibrillation (48 vs. 8%; p<0.001). They also had higher LV end-diastolic dimension (53±7 vs. 50±4 mm; p=0.009), LV mass (114±27 vs. 98±20 g/m2; p<0.001), left atrial size (47±7 vs. 38±6 mm; p<0.001), mitral E/Ea ratio (12.5±7 vs. 9.1±2.5; p=0.035) and the basal right ventricular end-diastolic dimension (39±8 vs. 31±5 mm; p<0.001) than those without HFPEF. HFPEF and increasing mitral E/Ea ratio was associated with increased mortality (Figure).Conclusions: HFPEF was present in 19% of COPD patients and is associated with poor long-term survival.