TY - JOUR T1 - Hand-held tidal breathing nasal nitric oxide measurement as a targeted case-finding tool for primary ciliary dyskinesia JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4610 AU - June K. Marthin AU - Kim G. Nielsen Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4610.abstract N2 - BACKGROUND: Nasal Nitric Oxide (nNO) measurement is a sensitive supplementary tool in diagnosis of Primary Ciliary Dyskinesia (PCD). Tidal Breathing (TB) nNO requires minimal cooperation, has potential as more widespread targeted case-finding tool for PCD in all age groups, and discriminative capacity between PCD and non-PCD has been previously established using stationary nNO analyzer (Marthin JK and Nielsen KG. Eur Respir J 2011; 37: 559-565).AIM: Assess validity of hand-held TBnNO in a selected population.METHODS: TBnNO was measured in PCDs, cystic fibrosis (CF) patients and healthy subjects (HS) using both an electrochemical hand-held device, NIOX MINO® Nasal equipped with a nasal research application, and two chemiluminiscence stationary systems: NIOX® and ANALYZER CLD 88sp®. All systems allow passive nasal sampling at a flow rate of 5 ml/s during tidal breathing. 2 ml/s sampling is an additional option with NIOX MINO® Nasal. Data were analysed by ROCC and Bland-Altman plots.RESULTS: TBnNO values were compared in 41 subjects between 0.3 and 57 years: 15 PCDs, 13 CF patients, and 13 HS. MINO discriminated significantly between PCD and HS (P<0.001) and between CF and PCD (P<0.001).View this table:CONCLUSION: Hand-held TBnNO separated significantly between PCD and HS, and between PCD and CF, with cut off value and sensitivity/specificity comparable to those of stationary systems. ER -