@article {BajoriunieneP2312, author = {Ieva Bajoriuniene and Kestutis Malakauskas and Simona Lavinskiene and Jolanta Jeroch and Edita Gasiuniene and Astra Vitkauskiene and Raimundas Sakalauskas}, title = {Peripheral blood Th17 cells and serum IL-17 levels in patients with D. pteronyssinus-induced late-phase asthmatic response}, volume = {40}, number = {Suppl 56}, elocation-id = {P2312}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Background. Biphasic cellular immune reaction which follows inhalation of allergen is the specific feature of allergic inflammation. Therefore, Th17 cells and IL-17 may have played a role in the development of the late-phase asthmatic response in patients with allergic asthma.Objectives. To evaluate the percentage of Th17 cells in peripheral blood (PB) and serum IL-17 levels in patients with D. pteronyssinus-induced late-phase asthmatic response.Methods. We studied 28 patients with allergic asthma who developed early-phase asthmatic response (EAR) (n=16) and late-phase asthmatic response (LAR) (n=12) after bronchial challenge with D. pteronyssinus. The control group included 10 healthy subjects (HS). PB collection was performed 24 h before as well as 7 h and 24 h after challenge. The percentage of Th17 cells was analyzed by FACS. Serum IL-17 levels were determined by ELISA.Results. View this table:Peripheral blood Th17 cells and serum IL-17 levels in patients with allergic asthma before and after bronchial challenge with D. pteronyssinus Conclusions. D. pteronyssinus-induced late-phase asthmatic response in patients with allergic asthma is associated with increased percentage of Th17 cells in PB and elevated serum IL-17 levels.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P2312}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P2312.full.pdf}, journal = {European Respiratory Journal} }